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Applications: Screen or profile small molecule inhibitors of MMP26
Background: MMP26 (also known as matrilysin-2 or endometase) is a member of the large family of matrix metalloproteinases (MMP) responsible for the breakdown of extracellular matrix proteins such as collagen. Most MMPs are secreted as inactive pro-proteins and are activated when cleaved by extracellular proteinases. MMP26 cleaves collagen type IV, vitronectin, fibronectin, and fibrinogen, among others. It also cleaves MMP9 for activation. MMPs are involved in tissue remodeling and in the escape of metastatic cells from the primary tumor. They are candidate therapeutic targets in various diseases related to tissue remodeling including cancer.
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The MMP26 (Matrix metalloproteinase 26) Fluorogenic Assay Kit is designed to measure MMP26 protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The kit contains enough recombinant MMP26 enzyme, substrate, and assay buffer for 96 reactions.
Uniprot: Q9NRE1
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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