Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and screening small molecule inhibitors and antibodies for drug discovery and HTS applications.
Background: Matrix metalloproteinase 3 (MMP3) is a zinc-dependent endopeptidase involved in the breakdown of extracellular matrix and tissue remodeling in normal physiological processes, such as embryonic development and reproduction, as well as in disease processes, such as arthritis and cancer. Overexpression of MMPs is associated with tumor invasion, neoangiogenesis and metastasis. Several inhibitors of MMPs (MMPI), small molecules and blocking monoclonal antibodies, have entered clinical trials. MMP3 (K45E) variant is associated with differences in MMP3 activity and has been linked to cancer susceptibility.
Description: The MMP3 (K45E) Inhibitor Screening Assay Kit is designed to measure the endopeptidase activity of MMP3 (K45E) for screening and profiling applications.
Storage Stability: Up to 6 months from date of receipt, when stored as recommended.
Supplied As: The MMP3 (K45E) assay kit comes in a convenient 384-well format, with purified MMP3 (K45E), its fluorogenic substrate, and MMP buffer for 384 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Nagase, H., et al. Biochemistry. 1990. 29(24): 5783-5789.
Mendes, O., et al. Clin Exp Metastasis. 2005. 22(3): 237-246.
Dormán, et al. Drugs. 2010. 70(8): 949-964.
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