Clone Number: HHF35
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: The antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with othermesenchymal cells except for myoepithelium. Muscle Specific Actin is a part of the actin family ofproteins which are highly conserved, major components of the cytoskeleton. Anti-Muscle Specific Actinimmunohistochemical reactivity is seen in skeletal, cardiac, and smooth muscle cells and can be seenin neoplasms with muscle differentiation such as leiomyomas and rhabdomyosarcomas. In contrast,antiMuscle Specific Actin reactivity is typically not seen in endothelial cells, connective tissues,carcinomas, melanomas, lymphomas and most nonmyogenic sarcomas
References: Gown AM, et al. Am J Pathol. 1986; 125:191/Schmidt RA, et al. Am J Pathol. 1988; 131:19-28/Azumi N, et al.Mod Pathol. 1988; 1:469-74
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