Mouse anti-Alpha-Synuclein, clone KM51 (monoclonal)

Clone Number: KM51

Immunogen: Prokaryotic recombinant protein corresponding to the majority of the full length alpha-synuclein molecule

Concentration: n/a

Storage buffer: Tissue culture supernatant with 15mM sodium azide

Additional info: Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a signal sequence suggesting that it is an intracellular protein. All synucleins have an unusual organization based around the eleven residue repeating motif and an alpha-helical secondary structure resembling those found in the lipid-binding domain of exchangeable apolipoproteins, including Apo E. This homology suggests a direct interaction of alpha-synuclein with membranes consistent with its affinity for synaptosomes.Clone KM51 is specific for alpha-synuclein and is unreactive with beta-synuclein. Pretreatment of tissue sections with 98-100% formic acid is also recommended.

References: Baba M et al. American Journal of Pathology. 152 (4): 879–884 (1998)/Polymeropoulos MH et al. Science. 276: 2045–2047 (1997)/Spillantini MG et al. Nature. 388: 839–840 (1997)

• SKU: SANMONX10739
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX10739
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1 kappa
• Host: Mouse
• Conjugate: Unconjugated