Clone Number: MRQ-3
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.Annexin A1 is a useful marker for identifying hairy cell leukemia cells. ANXA1 is strongly expressed onthe cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patientswith hairy cell leukemia, it is therefore a useful marker for identifying hairy cell leukemia cells. By contrast,B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villouslymphocytes and patients with variant hairy cell leukemia—as defined by current morphologic,phenotypic, and clinical criteria—are ANXA1-negative. Additionally, aberrant expression of Annexin A1has been reported in certain types of breast and gastric carcinomas.
References: Falini B, et al. Lancet.; 363:1869-70 (2004)/Sobral-Leite M, et al. BMC Med.; 13:156 (2015)/Cheng TY, et al. Cancer.; 118:5757-67 (2012)
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