Clone Number: LN22
Immunogen: Prokaryotic recombinant protein containing 1–350 amino acids of the N-terminus of the Bcl-6 human oncoprotein molecule.
Concentration: Greater than or equal to 220 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the Bcl-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
References: Capello D et al.Blood 2000, 95(2), 651-659/Allman D et al. Blood 1996, 87(12), 5257-5268
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