Clone Number: 17C2
Immunogen: Prokaryotic recombinant protein corresponding to a 160 amino acid region of the C-terminus of the beta-catenin molecule.
Concentration: Greater than or equal to 51 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.
References: Curia MC et al. Modern Pathology. 2008; 21:7-14/Ortega P et al. Clinical Cancer Research. 2008; 14(14):995-1001/Daa T et al. J. of Exp.Clin.Cancer Research. 2005; 24(1):83-87