Clone Number: 56C6
Immunogen: Prokaryotic recombinant fusion protein corresponding to the external domain of the human CD10 glycoprotein.
Concentration: n/a
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: CD10 antigen, also called neprilysin, is a 100 kD cell surface metalloendopeptidase which inactivates a variety of biologically active peptides. It was initially identified as the common acute lymphoblastic leukemia antigen (CALLA) and was thought to be tumor-specific. Subsequent studies, however, have shown that CD10 antigen is expressed on the surface of a wide variety of normal and neoplastic cells. In other lymphoid malignancies, CD10 antigen is reported to be expressed on cells of lymphoblastic, Burkitt's and follicular lymphomas. CD10 antigen has been identified on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. It is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. (G. McIntosh et al. American Journal of Pathology. 154(1): 77-82 (1999)).
References: Millar EK et al. Journal of Clinical Pathology 1999 52, 849-850/McIntosh GG et al. American Journal of Pathology 1999 154(1), 77–82/Kaufmann O et al. American Journal of Clinical Pathology 1999 111(1), 117-122
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