Clone Number: 87-6F9
Immunogen: stimulated human leucocytes
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: 87-6F9 Reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells tend to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory response through binding to ICAM 1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. When paired with CD18, it forms the integrin alphaLbeta2 adhesion. 87-6F9 Potently blocks LFA-1 dependent homotypic cell aggregation and was typed in the IVth International Leucocyte Typing Workshop
References: Knapp et al. (Eds.), Leukocyte Typing IV, 1989 : sections N1 (pp. 543.551)/Petruzzelli L et al. J Immunol 155(2): 854-866 (1995)/Edwards CP et al. J Biol Chem 273(44): 28937-44 (1998)
English
Deutsch
