Clone Number: CRIS-3
Immunogen: stimulated human leucocytes
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: Cris-3 reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells ten to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM-1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. When paired with CD18, it forms the integrin alphaLbeta2 heterodimer also called LFA-1. LFA-1 is chiefly responsible for lymphocyte adhesion.
References: Reinherz et. al., EL. Leukocyte Typing II. New York: Springer-Verlag (1985)/Jain et al. Folia Neuropathol 47(1), 33-42 (2009)
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