Clone Number: 2G9
Immunogen: Prokaryotic recombinant protein corresponding to the external domain of the human CD21 molecule.
Concentration: Greater than or equal to 326 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: CD21 antigen is a type I integral membrane glycoprotein of molecular weight 140 kD, which functions as the receptor for the C3d fragment of the third complement component. The CD21 molecule, present on mature B cells, is involved in transmitting growth-promoting signals to the interior of the B cell and acts as a receptor for Epstein-Barr virus. CD21 antigen is reported to be found in B cell chronic lymphocytic leukemias and in a subset of T cell acute lymphocytic leukemias but is absent on T lymphocytes, monocytes and granulocytes. CD21 antigen is also reported to be expressed in follicular dendritic cells and in follicular and mantle cell lymphomas, mature leukemias and lymphomas.
References: Dupin N et al. Proceedings of the National Academy of Sciences USA. 1999; 96(8); 4546–4551.
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