Clone Number: FR5A10
Immunogen: RAJI cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: FR5A10 reacts with CD21, a 140 kDa cell surface molecule which acts as a receptor for EBV, for human complement factor C3d (CR2) and for IFN-alpha. It is a glycoprotein, made up of multiple (n=15) Short Consensus Repeats (S.C.R.) sequences. FR5A10 has been assigned to (S.C.R.) sequences. FR5A10 has been assigned to S.C.R. numbers 5-8. FR5A10 is highly specific to CR2 and shows no cross-reaction with CR1. CD21 is expressed strongly on mature B-cells, follicular dendritic cells and weakly on immature thymocytes and T-lymphocytes. In B-cell ontogeny, CD21 appears after the preB-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B-cells in vitro.
References: Schlossman SF et al. Leukocyte Typing V Oxford University Press: 342-352 (1995)/Aubry JP et al. Leukocyte Typing V, p535-536, Oxford University Press, Oxford, (1995)
English
Deutsch
