Clone Number: EBS-CD-061
Immunogen: MCF-7 human breast cancer cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: Ep-CAM (also called ESA, EGP40, 17-1A antigen, KSA, GA7333-2) is a 40 kDa epithelial protein expressed on baso-lateral cell surfaces in very many epithelial tissues (but absent from mesothelial tissues). The 324AA have 3 potential glycosylation sites and is a transmembrane glycoprotein. The extracellular domain has a cysteine-rich repeat and a small domain with homology to nidogen. It is a homophilic cell-cell adhesion molecule (Ep-CAM). EBS-CD-061 reacts with most epithelial cells and carcinomas.
References: Edwards DP et. al. Cancer Res 46:1306-17 (1986)/Litvinov et al. J. Cell. Biol. 125: 437-446 (1994)/Tandon et al., Cancer Res. 50: 3317-3321 (1990)