Clone Number: NKI-P2
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: 100 ug/ml
Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide
Additional info: CD44, also designated Pgp-1 or H-CAM, is a broadly distributed 85 kD protein. Amongst haematopoietic cells CD44 is expressed on B and T lymphocytes, monocytes and neutrophils. Other CD44-positive cell types include epithelial cells, glial cells, fibroblasts and myocytes. This broad distribution suggest a general role in cell-cell and cell-matrix adhesion. CD44 is involved in T cell activation and adhesion. Triggering of CD44 increases homotypic T cell aggregation mediated via LFA-1. CD44 is linked to the cytoskeleton. Furthermore CD44 has an accessory role in lymphocyte adhesion to high endothelial venules.
References: Pals et al. J Immunol 1989;143:851/Pals et al. Blood 1989;73:885/Oostendorp et al/ Exp Hematol 1991;25:345
English
Deutsch
