Clone Number: Cris-1
Immunogen: stimulated human leukocytes
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: Cris-1 reacts with a 67 kDa protein, consistent with human CD5. Cris-1 was assigned at the Ist and IIIrd International Leucocyte Typing Workshops. CD5 is a pan T-cell marker that also reacts with a Bcell marker subset and a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large Bcell lymphoma. CD5 aberrant expression is useful in the diagnosis of mature T-cell neoplasms.
References: Proceedings of the first international workshop and conference on human leukocyte differentiation antigens. Oxford University Press, Oxford (1983)./Leukocyte Typing III, McMichael A. J. et al. (Eds.), Oxford University Press, Oxford (1987)/Alberola-Ila J, et al, J Immunol. 148(5): 1287-93 (1992)
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