Clone Number: 193-27
Immunogen: stimulated human leucocytes
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: CD59, or protectin, is a 18-22 kDa cell surface molecule on an GPI anchor. It regulates complementmediated cell lysis and is supposed to protect normal and tumor cells from cytotoxic attack by homologous complement through binding to C8 and C9. CD59 is expressed on leucocytes, vascular epithelium, a variety of epithelial cells and placenta. B-cell express low levels. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease Paroxysmal nocturnal hemoglobinuria (PNH). 193-27 Was typed at the VIth International Workshop on human leucocyte differentiation antigens.
References: Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)/Shichishima T. et al. Br J Haematol, 85(2):378-386 (1993)/Navenot JM. et al. Transfusion 38(4):337-342 (1998)
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