Clone Number: EBS-CD-034
Immunogen: stimulated human PBMC’s
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: EBS-CD-034 reacts with a complex of CD41 and CD61, i.e. alpha IIb integrin and the integrin beta chain. The MW of the GPIIIa is 105 kDa unreduced and 90 kDa reduced. The integrin beta 3 chain can also form a complex called the vitronectin receptor with integrin alpha V: the CD51/CD61 complex. Ligands are fibrinogen, fibronectin, von Willebrand factor, vitronectin and thrombospondin. Residues 237-248 of GPIIIa or CD61 are critical in adhesive protein binding. The CD51/CD61 complex is also found on endothelial cells, some B-cells, monocytes/macrophages and tumor cells.
References: Burns et al., Cell 45, 269 280 (1986)/McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, (1987)/Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press (1995)
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