Clone Number: EBS-CD-041
Immunogen: B lymphoblastoid cell line HFB1.
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: The CD74 cluster, established during the IVth and Vth Leukocyte Typing Workshops, comprises four species of proteins (MW 41/35/33 kDa), all coded by a single gene, consisting of nine exons. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. In tissue sections anti-CD74 show a binding pattern very similar to that of anti-HLA-DR. It binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. EBS-CD-041 epitope is localized in the extracellular domain of CD74.
References: Epstein A.L. et al. J. Immunol. 133: 1028-1036 (1984)/Marder, R.J. et al. Lab. Invest. 52: 497-504 (1985)/Lazova R. et al. Cancer 79: 2115-2124 (1997).
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