Mouse anti-Cytokeratin 5 (Liquid Primary Antibody), clone XM26 (monoclonal)

Clone Number: XM26

Immunogen: Prokaryotic recombinant fusion protein corresponding to a 103 amino acid portion of the C-terminal region of the human cytokeratin 5 molecule.

Concentration: Greater than or equal to 21 mg/L

Storage buffer: Tissue culture supernatant with Sodium azide

Additional info: Cytokeratins are a large family of cytoskeletal proteins found in epithelial cells. They are co-ordinately synthesized in pairs so that at least one member of each family is expressed in each epithelial cell. Cytokeratins assemble into obligatory heteropolymers composed of type I (acidic) and type II (basic) polypeptides to form higher order tetramers and protofilaments. Basal cells of human epidermis express acidic keratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kD protein that is closely related to cytokeratin 6. Point mutations in the cytokeratin 5 gene at locus 12q11-q13 can cause various types of epidermolysis bullosa simplex. Cytokeratin 5 is also reported to be expressed in most epithelial and biphasic mesotheliomas. Clone XM26 is specific for the 58 kD intermediate filament protein known as cytokeratin 5. It is not cross-reactive with cytokeratin 6.

References: Bhargava R et al. The American Journal of Clinical Pathology . 2008; 130:724-730/Laakso M e al. Clinical Cancer Research. 2006; 12(14):4185-4191/Miettinen M et al. American Journal of Surgical Pathology. 2003; 27(2):150–158

• SKU: SANMONX10670
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX10670
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1 kappa
• Host: Mouse
• Conjugate: Unconjugated