Mouse anti-Desmoglein-3, clone 5G11 (Monoclonal)

Clone Number: 5G11

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments. The monoclonal antibody 5G11 reacts with the 140 kDa desmoglein 3 protein. Furthermore it is not cross reactive with desmoglein 1 or desmoglein 2.

References: Wahl; J et al. Hybrid Hybridomics 2002; 21: 37

• SKU: SANMON3058
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON3058
• Green Labware: No
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry (paraffin), Immunoprecipitation, Western Blotting
• Isotype: IgG1
• Host: Mouse