Clone Number: K9
Immunogen: Prokaryotic recombinant protein corresponding to part of the C-terminus of the cytoplasmic domain of the human DOG-1 molecule.
Concentration: Greater than or equal to 12 mg/L
Storage buffer: Tissue culture supernatant with Sodium azide
Additional info: DOG-1, a 986 amino acid protein of unknown function, is expressed predominantly on the plasma membrane of gastrointestinal stromal tumors (GISTs) and is rarely expressed in other soft tissue tumors, which, due to appearance, can be confused with GISTs. Reactivity for DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express KIT antigen. The use of PBS-based diluents may result in increased background staining.
References: Novelli M et al. Histopathology. 2010; 57, 259-270/Miettinen M et al. American Journal of Surgical Pathology, 2009; 33, 1401-1408
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