Clone Number: 24D2
Immunogen: NIH-3T3/huCD340 cells
Concentration: 1 mg/ml
Format: Purified by protein-A affinity chromatography.
Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Additional info: The oncoprotein ErbB2/HER2 (human epidermal growth factor receptor 2), also known as Neu or CD340, is a 185 kDa transmembrane tyrosine kinase of cell surface growth factor receptor family. It is present in a wide variety cell types of normal human fetal and adult tissues and is frequently overexpressed in human carcinomas (e.g. in 20-30% cases of breast cancer cells). Activation of ErbB2 triggers intracellular signalling events, which are essential for cell growth and differentiation. In the last 20 years ErbB2 antigen has become very important marker and therapy target in patient care.SpecificityThe mouse monoclonal antibody CH3A4A7 recognizes an extracellular epitope of CD344 (Frizzled 4), a 7-TM protein of G-protein-coupled receptor family, which is a marker for neuronal stem cells.Application detailsFlow cytometry: Recommended dilution: 1-4 µg/ml
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