Clone: TME-2
Background: CD38 antigen is an integral membrane glycoprotein, M.W. 45 kD. The CD38 antigen is present on approximately all pre-B lymphocytes, plasma cells and thymocytes. CD38 antigen is also expressed on activated T Lymphocytes, NK Cells, monocytes, myeloblasts and erythroblasts. CD38 is co-expressed on CD34+ cells,but is not expressed on pluripotent stem cells. CD38 antigen is present on T and B lymphoblastic leukemia (ALL), Burkitts' lymphoma, multiple myeloma and acute myeloid leukemia (AML).
Purification Method: Protein A/G Chromatography
Concentration: Titered for flow cytometry
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein
References: 1) CD38 Molecule: Structural and Biochemical Analysis on Human T Lymphocytes, Thymocytes and Plasma Cells. J. Immunol, 1990 Aug; 145(3):878-84. Alessio, M. Roggero, S.; Funaro, A. ; De Monte L.B.,: Peruzzi, L.; Geuna, M.; Malavasi,F. 2) Differences Amoung Mononuclear Cell Subpopulations in HIV Seropositive or Seronegative Homosexual and Heterosexual men as Determined by Four Color Flow Cytometry. J. Acquir Immume Defic Syndr., 1990;3(8):747-56. Schnizlein-Bick, C.T.; Magier, M.R.; Jones, R.B.; Fife, K.H.; Katz, B., P.; Walker, E.B. 3) Quantitative Comparison of Myeloid Antigens on Five Lineages of Mature Peripheral Blood Cells. J. Leukoc Bio. 1990, Au;48(2):13848. Terstappen, L.W.; Hollander, Z.; Meiners, H.; Loken, M.R. 4) B-cell Surface Phenotypes of Proliferating Myeloma Cells: Target Antigens for Immunotherapy. Am. J. Hematol. 1990, Fe;33(2):1019, Chan, C.S; Wormsley, S.B.; Pierce, L. E.; Peter, J.B.; Schechter, G.P. 5) Interrelationships Between Serologic Markers of Immune Activation and T Lymphocyte Subsets in HIV Infection. J. Acquir Immune Defic Syndr. 1990;3(5):525-30. Prince, H.E.; Kleinman, S. Czaplicki, C.; John, J.; Williams, A.E. 6) Sequential Gererations of Hematopoietic Colonies Derived from Single Nonlineage-committed CD34+ CD38- Progenitor Cells. Blood 1991, Mar 1;77(6):1218-27. Terstappen, L.W.; huang, S.; Safford, M. Lansdorp, P.M.; Loken, M.R. 7) Involvement of Multilineage CD38 Molecule in a Unique Pathway of Cell Activation and Proliferation. J. Immunol, 1990 Oct 1;145(8):2390-6Funaro, A.; Spagnoli, G.C.; Ausiello, C.M.; Alessio, M.; Roggero, S.; Delia, D.; Zaccolo, M.; Malavasi, F. 8) Induction of CD4 and Susceptibility to HIV-1 Infection in Human CD8+ T Lymphocytes by Human Herpesvirus 6. Nat.349(6309): 5335, 1991. Lusso, P.; De Maria, A.; Malnati, M.; Lori, F.; DeRocco, S.E.;Baseler, M.; Gallo, R.C. 9) Circulating Antigen-Specific Suppressor T Cells in a Healthy Woman: Mechanism of Action and Isolation with a Monoclonal Antibody. Clin. Res. 29, 365a, 1981. Engleman, E. G.; Benike, C. J.; Evans, R.L 10) CD4 and CD8 Molecules Can Physically Associate with the Same T-cell Receptor. Proc. Nat. Acad. Sci. 1989, 86:10044.
UniProt: P28907
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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