Clone: E2E3.
Background: Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with full-length insulin protein and mouse myeloma cells.
Purification Method: Protein A/G Chromatography.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Roth, J., et al. 'Distribution patterns of proinsulin and insulin in human insulinomas: an immunohistochemical analysis in 76 tumors.' Virchows Arch B Cell Pathol Incl Mol Pathol 63, 51-61 (1992).
2. Nykiforuk, C.L., et al. 'Transgenic expression and recovery of biologically active recombinant human insulin from Arabidopsis thaliana seeds.' Plant Biotechnology J. 4, 77-85 (2006)
3. Lee, A.H., et al. 'XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands.' EMBO J., 24, 4368-4380 (2005).
UniProt: P01308.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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