Clone: C11.
Background: Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.
Purification Method:
Purified by saturated ammonium sulphate precipitation.
Source: Hybridoma produced by the fusion of splenocytes from mice immunized with cytoskeleton preparation from human A431 carcinoma cells and mouse myeloma cells.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Folia Biol. 1989, 35, 373-382
2. Neoplasma 1990, 37, 333-342
3. J. Tumor Marker Oncol. 1990, 5, 219
4. Int. J. Cancer 1988, Suppl. 3, 50-55.
UniProt: P13647.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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