Mouse anti-Human ZAP-70, clone L453R, L453R (monoclonal)

Clone Number: L453R

Immunogen: A prokaryotic recombinant protein corresponding to a portion of the N-terminus.

Concentration: Greater than or equal to 449 mg/L

Storage buffer: PBS with sodium azide

Additional info: ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.

References: Orchard J et al. Leukaemia and Lymphoma 2005; 46(12):1689–1698/Wang J et al. Applied Immunohistochemistry and Molecular Morphology 2005; 13(4):323–332/Mustelin T and Tasken K.Biochemical Journal 2003; 371:15–27

• SKU: SANMONX11109
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX11109
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG2b kappa
• Host: Mouse
• Conjugate: Unconjugated