Clone Number: 2D11
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: 100 ug/ ml
Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide
Additional info: The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro-inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.
References: Muzio; M et al. J Exp Med 1995; 182: 623 /Muzio, M et al Eur J Immunol 1999, 29: 781
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