Clone Number: 55
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: > 200 ug/ ml
Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide
Additional info: The monoclonal antibody 55 recognizes lipoteichoic acid (LTA). LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2. Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the cell surface.
References: Hogg;S et al. journal of systematic bacteriology 1997; 47:62/Langevelde, P et al Antimicrob Agents Chemother 1998, 42: 3073/Langevelde; P et al. Antimicrob Agents Chemother 1999; 43: 2984
English
Deutsch
