Mouse anti-Lyn, clone LYN-01 (Monoclonal)

Clone Number: LYN-01

Immunogen: Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).

Concentration: 1 mg/ml

Storage buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Additional info: Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.

• SKU: SANMON6032
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON6032
• Green Labware: No
• Package Unit: 0,1 mg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Monoclonal
• Application: Immunoprecipitation, Western Blotting, Immunocytochemistry
• Isotype: IgG1
• Host: Mouse