Clone Number: M2I-4
Immunogen: cMOAB/MRP2 amino acids 215-310
Concentration: 250 ug/ ml
Storage buffer: Serum free tissue culture supernatant with 0.7% BSA and 0.1% sodium azide
Additional info: M2I-4 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein known as the canalicular multi-organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2I-4 was raised against a bacterial fusion protein of cMOAB/MRP2, containing amino acids 215-310 of the protein. M2I-4 did not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.
References: Paulusma et al. Science 1996; 271: 1126-1128/Kool et al. Cancer Res 1997; 57: 3537-3547
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