Clone Number: MFG-06
Immunogen: milk fat globule membrane preparation derived from human breast cancer cell line PMC42
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: MFG-06 reacts with a glycoprotein of 40-45 kDa, known as Milk fat globule-EGF factor 8 protein (MFG-E8), lactadherin, p47 or milk fat globule 1 antigen. It is present on normal epithelial cells in various organs and considered a differentiation marker in carcinomas. It contains one EGF-like domain and 2 F5/8 type C domains. Functioning as a specific ligand for Integrin β5 and Integrin β3, MFG-E8 is thought to be involved in gamete interactions and cell attachment, possibly playing a role in fertilization and apoptosis. Additionally, MFG-E8 binds to rotavirus and inhibits its replication, thereby protecting the cell from viral infection. Overexpression of MFG-E8 is associated with breast cancer, suggesting that MFG-E8 may be related to tumorigenesis or progression. Among testicular carcinomas, seminomas are negative.
References: Bártková J, et. al. Tumour Biol. 8(1): 45-56 (1987)/Yamazaki, M. et al. Lab. Invest. 94: 1260-72 (2014)/Alfaro-Lira, S. et al. 2012. Int J Environ Res Public Health. 9: 1630-1648 (2012)
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