Clone Number: EBS-O-111
Immunogen: RAJI cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B-cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes
References: Thompson CJ et al., Human Immunol 6: 133-150 (1983)/Rask L, et al., Autoimmunity 8(3):237-244 (1991)
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