Clone Number: 47-8D3
Immunogen: human peripheral blood monocyte
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: 47-8D3 reacts with macrophages and detects the well-known leukocyte L1, cystic fibrosis antigen. Detecting a single protein band of 14 kDa in Western blots of lysates of human monocytes and granulocytes, the antigen was identified as the calcium-binding protein MRP14, which is a member of the S100 family involved a.o. in regulating the cell cycle. MRP14 is also implicated in the abnormal differentiation of myeloid cells in the stroma of cancer. It is further found on squamous mucosal epithelia. When associated with MRP8 it forms the heterodimer calprotectin.
References: Flavell DJ. et al., J. Histochem. Cytochem. 35: 1217-1226 (1987)/Facchetti F. et al., Am. J. Clin. Pathol. 92: 42-50 (1989)/Bardadin KA. et al., J. Pathol. 164: 253-259 (1991)
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