Clone Number: M2III-5
Immunogen: 202-amino acid COOH terminal of rat Mrp2
Concentration: 250 ug/ ml
Storage buffer: cell culture supernatant with 0.7% BSA and 0.1% sodium azide
Additional info: The antibody reacts with an internal epitope of MRP2, a 190-200 kD transmembrane protein earlier known as the canalicular multi-organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. M2III-5 was raised against a fusion protein of the bacterial maltose binding protein and rat Mrp2, containing the 202-amino acid COOH terminal end of the transporter protein. The Mab detects rat, mouse and human MRP2. M2III-5 does not cross-react with the human MDR1 P-gp, MRP1, MRP3 orMRP5 gene products.
References: Paulusma et al. Science 1996; 271: 1126-1128/Kool et al. Cancer Res 1997; 57: 3537-3547/Scheffer et al. Cancer Res 2000; 60: 5269-5277
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