Mouse anti-MSH2, clone G219-1129

Clone Number: G219-1129

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: MSH2 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-MSH2 antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.

References: Christensen M et al. Cancer 2002;95: 2422-30/Wright CL et al. Am J Surg Pathol. 2003;27: 1393-1406/Renkonen E et al. J Clin Oncol 2003; 21: 3629-3637

• SKU: SANMON-RTU1150
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON-RTU1150
• Package Unit: 7 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse
• Conjugate: Unconjugated