Mouse anti-p53, clone Pab122 (Monoclonal)

Clone Number: Pab122

Immunogen: SV40 infected 3T3 cells, 3T3/SV40 clone 4 (B4)

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: PAb 122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb 122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

References: Gurney et al, J. Virol. 34(3): 752-763, (1980)/Tack et al, J. Virol. 58(2): 635-45, (1986)

• SKU: SANMON7049
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON7049
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Monkey (Primate), Dog (Canine)
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry (frozen), Flow Cytometry
• Isotype: IgG2b
• Host: Mouse
• Conjugate: Unconjugated