Mouse anti-Poly (ADP - Ribose) Polymerase (PARP), clone A6.4.12 (Monoclonal)

Clone Number: A6.4.12

Conjugate: Purified

Immunogen: Human PARP-1

Concentration: 1.0 mg/ml

Storage buffer: PBS with 0.09% sodium azide

Additional info: Mouse anti poly (ADP-ribose) polymerase 1 antibody, clone A6.4.12 recognizes poly (ADP-ribose) polymerase 1 (PARP-1), a ~116 kDa nuclear enzyme, cleaved during apoptosis (Soldani et al. 2002). PARP-1, a caretaker enzyme, is involved in DNA damage repair (Langelier et al. 2013), plays roles in diabetes pathophysiology (Andreone et al. 2012) and tumour proliferation (Rosado et al 2013.).As well as protecting cells from genomic instability, PARP-1 is involved in the development of both inflammatory and immune responses, and cell death by apoptosis and necrosis (Erdélyi et al. 2005).Mouse anti poly(ADP-ribose) polymerase 1 antibody, clone A6.4.12, targets PARP-1, an enzyme which represents a promising target for new developments in therapeutic treatment of immune mediated diseases (Rosado et al. 2013). PARP-1 has considerable potential for delivering selective tumour cell killing while sparing normal cells (Pinton et al. 2013).

• SKU: SANMON8068
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON8068
• Green Labware: No
• Package Unit: 0,1 mg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Hamster, Frog (Xenopus Laevis), Fruit Fly (Drosophila Melanogaster)
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Immunoprecipitation, Western Blotting, ELISA
• Isotype: IgG1
• Host: Mouse