Clone Number: IPO-38
Immunogen: spleen cells of a patient with hairy cell leukemia
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: IPO-38 reacts with a 12-14 kDa protein, as found in Western blots of Raji cells, and appears in the mitotic cycle earlier than Ki-67. Lymphocytes, induced to early G1 phase by 12h exposure to PHA, will become positive while non-stimulated lymphocytes remain negative. Mononuclear cells and granulocytes of healthy donors are negative, while various forms of leukemia and lymphoma including Hodgkin’s disease are positive for IPO-38, as are many solid tumors such as some breast, gastric and colonic cancers for which it may serve as tumor progression marker.
References: Sidorenko, S.P. et al., Gematol. Transfuziol. 35: 19-22 (1990)/Sidorenko, S.P. et al., Experem. Oncol. 16: 145-150 (1994)/Thosaporn W., et al., Oral Dis. 10(1): 22-6 (2004)
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