Clone Number: SPT24
Immunogen: Prokaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule.
Concentration: Greater than or equal to 108 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98% homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities.
References: Unal B et al. Turkish Journal of Pathology. 2014; 30(3): 201-205/Klingen TA et al. Diagnostic Pathology. 2013; 8: 80-86/Berghmans T et al. Lung Cancer. 2006; 52(2): 219-224
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