Clone Number: AE-5
Immunogen: nuclei of myeloid leukemia biopsy cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, a mRNA differentially expressed in F9 embryonal carcinoma cells, and that is up-regulated during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1- pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
References: Yamada, K., et al. Biochem. Biophys. Res. Commun. 280: 1169-1176 (2001)/Ohkura, T., et al. Biochem. Biophys. Res. Commun. 321: 432-440 (2004)
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