Clone Number: VEGF-21
Immunogen: human VEGF189 recombinant protein
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: VEGF-21 reacts with Vascular Endothelial Growth Factor, also known as Vascular Permeability Factor (VEGF/ VPF) and is the key mediator of angiogenesis. The MWs are 19- 22kDa (reducing) and 38kDa-44kDa (non-reducing). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis. In addition to endothelial cells, VEGF and VEGF receptors are expressed on numerous non-endothelial cells including tumor cells.
References: Tischer E. et al. J. Biol. Chem 266: 11947-11954 (1991)/Berse B. et al, Mol. Biol. Cell 3: 211-220 (1992)/Folkman J. et al, Nature 339: 58-61 (1989)
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