Clone: 10
Background: Yeast Tup 1p-Ssn6p repressor complex represents a novel paradigm for transcriptional repression and for the role of chromatin in repression. TUP 1 and SSN6 are involved in repression of several diverse families of genes in yeast, including cell type-specific genes regulated by the alphga2 and a1/alpha2 repressors. Ssn6-Tupl interacts with class I histone deacetylases required for repression, and rfecrfuitment of yeast Tuplp-Ssn6p repressor is associated with localized decreases in histone acetylation.
Positive Control: Mav108 cells expressing recombinant TUP1 protein
Immunogen: Recombinant protein derived from the amino acids 1-200 of yeastt TUP1 protein
Purification Method: Protein A/G Chromatography
Concentration: See vial for concentration
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
References: 1. Bone, J.R. and Roth, S.Y. 'Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation.' J. Biol. Chem 2001, 276, 1808-18132. Watson, A.D., et al. 'Ssn6-Tup1 interacts with class I histone deacetylase required for repression.' Genes and Development 2000, 14, 2737-27443. Yang, X., et al. 'Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: Coupling protein O-GlcNAcylation to transcriptional repressor.' Cell 2002, 110, 69-804. DeSilva, H., et al. 'Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.' Genetics 1998, 148, 657-667
UniProt: P16649 (Yeast-Saccharomyces cerevisiae)
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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