Formulation: A solid
Formal Name: 1-[3-methoxy-4-[[6-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-9H-purin-2-yl]amino]phenyl]-4-piperidinol
Purity: ≥98%
Formula Markup: C26H31N7O4S
Formula Weight: 537,6
Shelf life (days): 1460
CAS Number: 1609584-72-6
Notes: Mps1-IN-3 is an inhibitor of monopolar spindle 1 (Mps1; IC50 = 50 nM).{72400} It inhibits the proliferation of U251 glioblastoma cells (IC50 = ~5 µM). Mps1-IN-3 (2 µM) prevents checkpoint-mediated mitotic arrest induced by nocodazole (Item No. 13857) in U2OS osteosarcoma cells and, when used at a concentration of 5 µM in combination with the antimitotic agents vincristine (Item No. 11764) or paclitaxel (Item No. 10461), induces nuclear aberrancies and chromosome missegregation defects in U251-FM-H2B-GFP cells, which express firefly luciferase, mCherry, and a histone H2B-GFP fusion reporter. It sensitizes U251-FM cells to vincristine and increases survival in an orthotopic mouse model of glioblastoma when administered at a dose of 2 mg/kg.
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