MS-436, CAS 1395084-25-9

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CAS Number: 1395084-25-9

Description: MS-436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS-436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC₅₀ values are 3.8 and 4.9 µM, respectively). MS-436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.

Format: Solid

Purity: 0,98

Storage Stability: At least 6 months at -20°C. 

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• SKU: BPS82061-2
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 82061-2
• Package Unit: 250 mg
• Quantity Unit: STK