MS417, CAS 916489-36-6

Product Description: MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM).

Applications: COVID-19-anti-virus

Formula: C20H19ClN4O2S

References: [1]Zhang G, et al. Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51.

CAS Number: 916489-36-6

Molecular Weight: 414.91

Compound Purity: 99.79

Research Area: Infection; Inflammation/Immunology

Solubility: 10 mM in DMSO/Ethanol : 50 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;HIV

• SKU: MEXHY-111139-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-111139-50
• Package Unit: 50 mg
• Quantity Unit: STK