Clone Name: ZR201
Product Description: Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of mucin 4results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of mucin 4 in pancreatic carcinoma by alltrans-retinoic acid is mediated through the retinoic acid receptor-å signaling pathway. MUC-4 is a very specific (100%) andsensitive (90%) marker of lung adenocarcinomas and is negative for mesotheliomas. MUC4 is expressed in many human adenocarcinomas. It is specifically expressed in lowgrade fibromyxoid sarcoma. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
Calculated MW: 232
Positive Control: Colon
Form: Liquid
Buffer (with preservative): Tris‐HCl buffer, 0.2% BSA, 0.09% sodium azide.
Concentration: batch dependent (Please refer to the vial label for the specific concentration.)
Background: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
Uniprot ID: Q99102
Antigen Species: Human
Immunogen: Recombinant fragment (around aa 1730-1864) of human MUC4 prote
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: mucin 4, cell surface associated
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