Product Type: Inhibitor
CAS No.: 128794-94-5
MolecularFormula: C23H31NO7
Molecular Weight: 433,5
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (40 mg/ml); or ethanol (4 mg/ml)
Appearance: White powder
PubChem CID: 5281078
Scientific Background: Mycophenolate mofetil is an immunosuppressive agent useful in prevention of organ allograft rejection (1). It is metabolized to mycophenolic acid in vivo, which acts by inhibiting the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). It also inhibits IL-2-dependent T cell proliferation (4), and microglial and astrocytic activation reducing cell death after neuronal injury (5). It also prevents neuroinflammation.
References: 1. Allison A.C., and Eugui, E.M. (1996) Clin. Transplant. 10:77.2. Jonsson C.A., et al., (2002) Cell. Immunol. 216:93.3. Allison A.C., et al., (1993) Ann. NY Acad. Sci. 696:63.4. Quemeneur J., et al., (2002) J. Immunol. 169:27475. Ebrahimi F., et al., (2012) J. Neuroinflammation 9:89.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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