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Encompassing Amino Acids: 2-445(end)
Applications: Useful for studying protein binding and screening small molecules for drug discovery.
Background: MYLIP is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Its activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibition of neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Description: Human MYLIP, also known as Inducible Degrader of the LDL receptor (IDOL), GenBank Accession No. NM_013262, a.a. 2-445(end), with N-terminal His-FLAG-tag, MW=51.7 kDa, expressed in a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 µg/ml FLAG peptide, and 20% glycerol.
Genbank: NM_013262
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-FLAG-tag
Uniprot: Q8WY64
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Santos PC., et al. Lipids Health Dis. 2012;11:83.
2. Sorrentino V., et al. Eur Heart J. 2013;34(17):1292-7.
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