Product Type: Inhibitor
CAS No.: 35891-70-4
MolecularFormula: C21H39NO6
Molecular Weight: 401,54
Source: Synthetic
Purity: >98%
Solubility: Soluble in 2 mg/ml of methanol, DMSO (25 mg/ml;heat briefly in boiling waterbath) or in dilute base(5 mg/ml; 50 mM NaOH)
Appearance: Off-White Solid
PubChem CID: 6438394
Scientific Background: Myriocin, or ISP-1, is an atypical amino acid and an antibiotic. It is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis (1). It was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. It also possesses immunosuppressant activity (2).
References: 1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641.2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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