Formulation: A solid
Formal Name: 4-[(4-aminophenyl)sulfonyl]-N-hydroxy-benzenamine
Purity: ≥98%
Formula Markup: C12H12N2O3S
Formula Weight: 264,3
Shelf life (days): 730
CAS Number: 32695-27-5
Notes: N-hydroxylamine Dapsone is an active metabolite of dapsone (Item No. 23743).{62799} It is formed via N-hydroxylation of dapsone by the cytochrome P450 (CYP) isoforms CYP2C8, CYP2C9, CYP2C18, and CYP2C19 in the liver.{62798} N-hydroxylamine Dapsone is cytotoxic to rat hepatocytes (LC50 = 3.6 mM).{62800} It induces hemolysis in isolated human erythrocytes at a concentration of 100 µM.{62799} N-hydroxylamine Dapsone induces phosphatidylserine (PS) exposure on the outer membrane, a marker of apoptosis and platelet activation, and increases the production of reactive oxygen species (ROS) in a concentration-dependent manner in isolated human erythrocytes. It increases thrombus weight in a rat model of surgically induced thrombosis when administered at a single dose of 50 mg/kg or at a dose of 10 mg/kg per day for four days.
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